As I already told I'm using policyd-weight for SPAM protection purposes. Since I'm always curious how it behaves I use the mailgraph to get some statistics from my logs.
If you look on the number of past week's sent and received mails is approx. 0.13 mail/minute.

Most spammers are very aggressive in terms of connection and re-connection to mail servers. Of course they want to send as many SPAM as possible in the shortest time period.
However if you're using postfix you can throttle that by being a bit more restrictive in your anvil settings in main.cf
smtpd_client_connection_count_limit = 2 smtpd_client_connection_rate_limit = 1 anvil_rate_time_unit = 45s
Found at policyd stats
main.cf and you're done.
If you run your own mail server you have to think carefully about SPAM protection of course. The first line of defence is in front of the actual mail server or at least before accepting the actual mail body.
The problem is that in some countries the mail mustn't be rejected or dropped after the mail server accepted the mail from the outside. Therefore techniques like RBL or greylisting could help here.
Another option is using policyd-weight. This is a
Da bin ich doch gerade über einen interessanten Beitrag zu msmtp vom gestolpert.
Er erklärt kurz und knapp wie ich mutt auf einer beliebiegen Maschine nutzen kann und doch meinen eigenen Mailserver nutzen.
Muss ich mal antesten...
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